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A young man and woman with depression symptoms stand in profile

Request depression medication or renew a prescription online

Out of refills of medication you take for depression? Connect with a telehealth provider about renewing your prescription for depression treatment

How it works

Start your health intake
Request On-Demand Care 24/7—no appointment needed.
Discuss with a provider
Review your health concern or treatment request with a One Medical provider via message or video.
Get treatment
Receive your care plan. If appropriate, prescriptions are sent to your pharmacy or delivered to your door with Amazon Pharmacy (if eligible).
Smiling One Medical provider delivers telehealth care

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Young woman with depression symptoms meditates on a yoga mat indoors.

What is depression?

Depression is more than just feeling down or having a bad day. It’s a feeling of deep and persistent sadness that interferes with normal, everyday functioning.
Depression is common. According to the National Institute of Mental Health (NIMH), every year about 21 million U.S. adults experience at least one episode of major depression. While the exact causes vary, depression often involves an imbalance of brain chemicals that can be triggered by life events, genetics, or other factors.

An overview of depression

It’s important to remember that depression isn't anyone’s fault and it’s okay to ask for help. In some cases, antidepressant medication may be an important part of treatment. Other treatment approaches could include cognitive behavioral therapy (CBT), nutrition counseling, practicing good sleep habits, or mindfulness coaching. Amazon One Medical providers can work with you to create a custom mental health treatment plan that you feel comfortable with.
Depression can cause a wide range of symptoms, including:
• Feeling sad most of the time
• Not enjoying things you used to enjoy
• A change in appetite
• Sleep changes
• Feeling unusually tired
• Feeling guilty or worthless
• Difficulty focusing
• Having trouble staying still or moving or speaking more slowly than usual
• Rarely, thoughts of hurting yourself

Is online prescription renewal right for me?

You're 18-64
You need a prescription renewal for a depression and/or anxiety medication you've taken within the past 4 days
You've discussed your mental health needs with a licensed healthcare provider within the past 2 years
Over the past 2 weeks, your depression and anxiety symptoms have felt controlled*
You're not pregnant
*If you're experiencing a mental health crisis, please see a doctor immediately or call 911. You can also call or text the National Suicide Prevention Lifeline 24/7 at 988.

Common depression and anxiety medications (antidepressants)

Your Amazon One Medical provider will determine which (if any) depression treatment is medically appropriate for you based on your symptoms and health history. If you're prescribed medication, your provider will send the prescription to your preferred pharmacy. Choose Amazon Pharmacy for free delivery and transparent Prime pricing. The cost of your prescribed medication is not included with the treatment cost and may be covered by health insurance.
These are the only psychotropic medications available for prescription renewal through On-Demand Care.
Pill bottle icon
SSRIs
Selective serotonin reuptake inhibitors
• Citalopram (Celexa)
• Escitalopram (Lexapro)
• Fluoxetine (Prozac)
• Paroxetine (Paxil)
• Sertraline (Zoloft)
Pill bottle icon
SMSs
Serotonin modulators and stimulators
• Vilazodone (Viibryd)
• Vortioxetine (Trintellix)
Pill bottle icon
NDRIs
Norepinephrine–dopamine reuptake inhibitors
• Buproprion (Wellbutrin)
Pill bottle icon
SNRIs
Serotonin–norepinephrine reuptake inhibitors
• Desvenlafaxine (Pristiq)
• Duloxetine (Cymbalta)
• Levomilnacipran (Fetzima)
• Venlafaxine (Effexor XR)
Pill bottle icon
TeCAs
Tetracyclic antidepressants
• Mirtazapine (Remeron)

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Not sure where to start?

For a one-time fee of $59, an Amazon One Medical provider can diagnose and treat common health complaints, renew prescriptions, and answer your questions in real time. Restrictions apply.
Get urgent virtual care ›

Frequently asked questions

About Amazon One Medical

How can I request online or in-person depression treatment from Amazon One Medical?
If you're an Amazon One Medical member, 24/7 On-Demand Care is included in your membership. On-Demand Care has two telehealth pathways: Direct Message Care connects you to a provider through async messaging, and Video Care connects you to a provider in real time.
If you're an Amazon One Medical member and you live in a state where One Medical has offices, you can also get medical treatment through In-Person Visits or Scheduled Video Visits, both billable to you or your health insurance.
If you're not an Amazon One Medical member, you can still get 24/7 On-Demand Care for 30+ common health conditions by paying as you go for online treatment. To see the Direct Message Care and Video Care options where you live, get started from a condition detail page and choose your state.
*Direct Message Care availability varies by state. Prices subject to change.
Where are scheduled visits available? Is there a One Medical office near me?
In-person Visits are scheduled appointments with the provider of your choice. Video Visits are scheduled, virtual appointments with the provider of your choice and are available in U.S. states where One Medical offices are located.
One Medical currently has primary care doctors' offices in or around the following locations:
•
Atlanta, GA
•
Austin, TX
•
Boston, MA
•
Chicago, IL
•
Columbus, OH
•
Connecticut
•
Dallas-Ft. Worth, TX
•
Houston, TX
•
Los Angeles, CA
•
Miami-Ft. Lauderdale, FL
•
New Jersey
•
New York
•
Orange County, CA
•
Phoenix, AZ
•
Portland, OR
•
Raleigh-Durham, NC
•
San Diego, CA
•
Seattle-Tacoma, WA
•
San Francisco Bay Area, CA
•
Washington D.C. Metro Area (DMV) and Northern Virginia
In-person and Video Visits are not included in membership and are billed to you/your insurance; copays and deductibles may apply.
Find out more about One Medical locations, including One Medical Seniors offices, on the location page.
Can I use my health insurance to pay for Amazon One Medical On-Demand Care (formerly Pay-per-visit)?
Amazon One Medical doesn't accept health insurance for On-Demand Care, its 24/7 telehealth service. If you were charged for treatment as a non-member, you can submit a claim to your insurance provider for reimbursement, but we can’t guarantee they’ll reimburse you for treatment.
If you use insurance to pay for your medications, you can do that with medications prescribed through all Amazon One Medical services. Amazon Pharmacy accepts most insurance plans. For other pharmacies, please talk with your pharmacy directly about insurance coverage. The cost of medication isn’t included in the cost of your medical care.
What's the virtual prescription renewal policy at Amazon One Medical On-Demand Care?
Amazon One Medical providers typically write prescription renewals for a 30-day or 90-day supply of medication.
Your provider will consider many factors when determining if a prescription is medically appropriate. For example, they may want to know how long it's been since you've:
• Taken your medication
• Seen your regular primary care provider
• Had appropriate lab testing
• Had your last prescription renewal through On-Demand Care*
When you request a prescription renewal, you'll need to provide details about your last prescription, including the medication name, the dose, and the directions on the label.
There may be a limit to the number of renewal requests that a provider can evaluate during a treatment. On-Demand Care providers will not renew prescriptions that require a prior authorization from your insurance company.
*Prescription renewals will be limited to one 90-day refill or two 30-day or less refills within a 12-month period.
What's the difference between a renewal and a refill?
When you run out of your medication, you refill it through a pharmacy. When you run out of refills, a licensed healthcare provider has to renew your prescription.
You can request a remote prescription renewal through Amazon One Medical On-Demand Care. Your provider will send any new prescriptions to a U.S. pharmacy of your choice. You pay for the medication when you pick it up or have it delivered.
Can I get mental health treatment through Amazon One Medical On-Demand Care?
No. You can't see a mental health provider for behavioral therapy, psychiatry, counseling, coaching, clinical social work, or other mental health specialties through Amazon One Medical On-Demand Care. For mental health care, you'll need to see a primary care provider or a mental health care provider for guidance.
If you've taken a medication for depression or anxiety within the past 4 days, you can request a prescription renewal through On-Demand Care, but your provider won't adjust or initiate medication.
Your On-Demand Care provider won't renew prescriptions for stimulants like Adderall for ADHD, benzodiazepines like Xanax, antipsychotics like quetiapine (Seroquel) or aripiprazole (Abilify), mood stabilizers like lithium, or nerve pain medications like gabapentin (Neurontin) or pregabalin (Lyrica).
What depression and anxiety medications can be renewed through On-Demand Care?
When medically appropriate, your Amazon One Medical On-Demand Care provider may renew prescriptions for the following psychotropic medications:
• Buproprion (Wellbutrin)
• Buspirone (Buspar)
• Citalopram (Celexa)
• Desvenlafaxine (Pristiq)
• Duloxetine (Cymbalta)
• Escitalopram (Lexapro)
• Fluoxetine (Prozac)
• Hydroxyzine (Vistaril)
• Levomilnacipran (Fetzima)
• Mirtazapine (Remeron)
• Paroxetine (Paxil)
• Propranolol (Inderal)
• Sertraline (Zoloft)
• Venlafaxine (Effexor XR)
• Vilazodone (Viibryd)
• Vortioxetine (Trintellix)
How does Amazon One Medical protect my health information?
Amazon One Medical protects customers’ protected health information (PHI) with stringent, Health Insurance Portability and Accountability Act (HIPAA)-compliant privacy and security practices to keep information safe and secure.
We’re committed to building an infrastructure that fosters and promotes a culture of customer privacy and a strong commitment to safeguarding health information. We maintain administrative, physical, and technical safeguards to protect customer information. This includes conducting rigorous security reviews and testing during product development, using encryption to protect data, and providing features like two-step verification to help customers protect their accounts.
Amazon does not sell customers’ personal information, including PHI.

About depression treatment

What causes depression and who is at risk?
Research suggests that depression is likely caused by an imbalance of chemicals in the brain. Although it can affect people of all ages, races, ethnicities, and genders, depression is thought to be more likely in people with a history of trauma or stressful events and in those with a personal or family history of mental health problems.
Why should I see a primary care provider for my mental health?
Primary care providers are trained to see the big picture. They can identify when your mental health is affecting your physical health and vice versa. For example, things like low libido, digestive problems, and headaches can be made worse by mental health conditions like depression or anxiety. Amazon One Medical’s team of primary care providers are specially trained to deliver excellent, comprehensive care for a range of mental health conditions.
How is depression diagnosed?
Depression is diagnosed by a healthcare provider based on your symptoms. During your visit, your provider will ask some questions about how you’ve been feeling lately and how changes in your mood have impacted your everyday life. They’ll also ask questions about your health history, including medications you take regularly, alcohol or drug use, and any other medical or mental health conditions you’ve been diagnosed with. Additional testing is generally not needed but sometimes may be considered to rule out other possible causes for your symptoms.
What are some things I can do on my own to help me feel better?
When you're experiencing symptoms of depression, there are a variety of things you can do on your own to help you feel better. Try reading about techniques to help you manage negative thoughts. Physical activity like playing sports, going for a walk, or riding a bike can help improve your mood and give you more energy. Relaxation techniques like deep breathing, meditation, or yoga can help reduce stress and tension. Eating regular and nutritious meals and keeping a regular sleep schedule can help you feel more energized and think more clearly.
Spending time with people who care about you can provide support and make you feel less alone. Identify people that you trust and consider talking with them about how you’re feeling. Sometimes, talking to other people who are going through the same thing can help, so you may consider attending a support group.
If I decide to start depression medication, when will I feel better?
A healthcare provider will determine if you need prescription medication to treat your symptoms of depression. If your care plan includes a prescription, you'll be asked to select a pharmacy. You can send it to your preferred pharmacy or select Amazon Pharmacy to get your medications delivered right to your door.
What about therapy?
In general, combining antidepressant medication with therapy is more effective than either alone, and therapy can also help you find ways to cope while waiting for your medication to start working. Amazon One Medical has a referral network of therapists and psychiatrists whom we know and trust that we can connect you to. And we’ll be there with you every step of the way.
If I’m prescribed medication for treatment, do I have to be on it for the rest of my life?
It depends. Everyone is different, and the length of time you might need to take medication can vary. Some people take antidepressants for a few months, while others might need them for a few years. It depends on how you feel and how your body responds to the treatment. Your provider will check in on you routinely and partner with you to decide if and when it may be safest to try managing your symptoms without medication. It’s important to remember to talk with your provider before stopping any antidepressant medication.
What treatment options for depression are available to those who are pregnant?
If you’re pregnant or planning for pregnancy, let your provider know. Treating depression during pregnancy is important for both the parent’s and baby’s health. Your provider will partner with you to determine which treatment is best for you and safest for your pregnancy.
What do I do if I have thoughts of hurting myself or others?
If you ever have thoughts of harming yourself or feel that life is too hard to keep living, or you’re in crisis and need to speak with someone immediately, help is available! Go to your nearest emergency room or call or text 988 to reach the National Suicide and Crisis Lifeline. You can also reach a trained crisis counselor by texting HOME to 741741. These services provide free, confidential crisis counseling 24/7. In less urgent situations, your healthcare provider can help you create a suicide safety plan that you can lean on when things get tough.
What if I’m concerned that a friend or family member may want to hurt themselves?
If you suspect a loved one is experiencing suicidal thoughts, the best thing to do is listen to them and ask questions. If your conversation leaves you feeling concerned or worried for your loved one’s safety, get a professional involved. Urge them to book an appointment with a therapist or other trusted provider, or offer to do it for them. If you sense there is an immediate risk of suicide or self-harm, call 911.
You can learn more about supporting a loved one who’s struggling with their mental health on the One Medical blog.
Clinical sources
1. Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J. P. T., Egger, M., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Tajika, A., Ioannidis, J. P. A., & Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet (London, England), 391(10128), 1357–1366.
2. U.S. Department of Health and Human Services. (n.d.). Major depression. National Institute of Mental Health. https://www.nimh.nih.gov/health/statistics/major-depression
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