Your account has an Amazon One Medical Membership

On-Demand Care for this condition is included with membership

With your membership you can:

Get 24/7 On-Demand Care
Convenient prescription refill and renewal requests
View a summary and action items after your treatment, and directly message your care team
A young man and woman with depression symptoms stand in profile

Depression medication

Share your renewal request with Health AI and get a prescription from a provider if appropriate.

How it works

Check-in with Health AI
Complete a check-in with the help of Health AI.
Discuss with a provider
Review your health concern or treatment request with a One Medical provider via message.
Get treatment
Receive your care plan. If appropriate, prescriptions are sent to your pharmacy and, if you use Amazon Pharmacy, delivered to your door (if eligible).
Smiling One Medical provider delivers telehealth care

Common depression and anxiety medications (antidepressants)

Your Amazon One Medical provider will determine which (if any) anxiety treatment is medically appropriate for you based on your symptoms and health history. If you're prescribed medication, your provider will send the prescription to your preferred pharmacy. Choose Amazon Pharmacy for free delivery and transparent Prime pricing. The cost of your prescribed medication is not included with the treatment cost and may be covered by health insurance.
These are the only psychotropic medications available for prescription renewal through On-Demand Care.
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SSRIs

Selective serotonin reuptake inhibitors
• Citalopram (Celexa)
• Escitalopram (Lexapro)
• Fluoxetine (Prozac)
• Paroxetine (Paxil)
• Sertraline (Zoloft)
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SNRIs

Serotonin–norepinephrine reuptake inhibitors
• Desvenlafaxine (Pristiq)
• Duloxetine (Cymbalta)
• Levomilnacipran (Fetzima)
• Venlafaxine (Effexor XR)
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SMSs

Serotonin modulators and stimulators
• Vilazodone (Viibryd)
• Vortioxetine (Trintellix)
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NDRIs

Norepinephrine–dopamine reuptake inhibitors
• Buproprion (Wellbutrin)
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TeCAs

Tetracyclic antidepressants
• Mirtazapine (Remeron)

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Young woman with depression symptoms meditates on a yoga mat indoors.

What is depression?

Depression is more than just feeling down or having a bad day. It’s a feeling of deep and persistent sadness that interferes with normal, everyday functioning.
Depression is common. According to the National Institute of Mental Health (NIMH), every year about 21 million U.S. adults experience at least one episode of major depression. While the exact causes vary, depression often involves an imbalance of brain chemicals that can be triggered by life events, genetics, or other factors.

An overview of depression

It’s important to remember that depression isn't anyone’s fault and it’s okay to ask for help. In some cases, antidepressant medication may be an important part of treatment. Other treatment approaches could include cognitive behavioral therapy (CBT), nutrition counseling, practicing good sleep habits, or mindfulness coaching. Amazon One Medical providers can work with you to create a custom mental health treatment plan that you feel comfortable with.
Depression can cause a wide range of symptoms, including:
• Feeling sad most of the time
• Not enjoying things you used to enjoy
• A change in appetite
• Sleep changes
• Feeling unusually tired
• Feeling guilty or worthless
• Difficulty focusing
• Having trouble staying still or moving or speaking more slowly than usual
• Rarely, thoughts of hurting yourself

Frequently asked questions

What depression and anxiety medications can be renewed through On-Demand Care?
When medically appropriate, your Amazon One Medical On-Demand Care provider may renew prescriptions for the following psychotropic medications:
• Buproprion (Wellbutrin)
• Buspirone (Buspar)
• Citalopram (Celexa)
• Desvenlafaxine (Pristiq)
• Duloxetine (Cymbalta)
• Escitalopram (Lexapro)
• Fluoxetine (Prozac)
• Hydroxyzine (Vistaril)
• Levomilnacipran (Fetzima)
• Mirtazapine (Remeron)
• Paroxetine (Paxil)
• Propranolol (Inderal)
• Sertraline (Zoloft)
• Venlafaxine (Effexor XR)
• Vilazodone (Viibryd)
• Vortioxetine (Trintellix)
Clinical sources
1. Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J. P. T., Egger, M., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Tajika, A., Ioannidis, J. P. A., & Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet (London, England), 391(10128), 1357–1366.
2. U.S. Department of Health and Human Services. (n.d.). Major depression. National Institute of Mental Health. https://www.nimh.nih.gov/health/statistics/major-depression