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EpiPen injected into thigh

Epinephrine and EpiPens

Share your renewal request with Health AI and get a prescription from a provider if appropriate.

How it works

Check-in with Health AI
Complete a check-in with the help of Health AI.
Discuss with a provider
Review your health concern or treatment request with a One Medical provider via message.
Get treatment
Receive your care plan. If appropriate, prescriptions are sent to your pharmacy and, if you use Amazon Pharmacy, delivered to your door (if eligible).
Smiling One Medical provider delivers telehealth care

Commonly prescribed EpiPens

Your Amazon One Medical provider will determine which (if any) epinephrine auto-injector prescription renewal is medically appropriate for you or your child based on symptoms and health history. If you're prescribed medication, your provider will send the prescription to your preferred pharmacy. Choose Amazon Pharmacy for free delivery and transparent Prime pricing. The cost of any prescribed medication is not included with the treatment cost and may be covered by health insurance.
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Epinephrine auto-injectors

• Adrenaclick
• AUVI-q (voice-guided)
• EpiPen
• EpiPen generic
• Symjepi
Red-headed child with allergy symptoms embraces her mother

Can I get an EpiPen renewal for my child?

Yes, if you are a parent or legal guardian who can manage care for the child. Your child must be between ages 2 and 11 years old.
Having a valid EpiPen prescription is an important part of minimizing your child’s risk of having a life-threatening allergic reaction (anaphylaxis). Having an EpiPen on hand to treat an allergic reaction right away is critical.
Mom does online Epipen prescription renewal visit for her child who needs an epipen on her mobile phone

Who needs an EpiPen?

EpiPens are prescribed to people who are at risk of having a severe and potentially fatal allergic reaction called anaphylaxis.
If you've already experienced anaphylaxis and you might encounter the triggering agent again, then healthcare providers recommend that you keep an epinephrine auto-injector on hand. It could keep you out of the hospital, or even save your life.
If you've already experienced anaphylaxis and you don't know what triggered the allergic reaction, you also need an EpiPen in case you encounter the unknown trigger again.

How are EpiPens prescribed?

Epinephrine, also known as adrenaline, is prescribed to adults and children as a 2-pack of prefilled pen syringes or auto-injectors. Epipens are offered in weight-based child and infant doses. Regular EpiPens can also be prescribed to children weighing over 66 pounds. For children who are between the weight of 33-66 pounds, EpiPen Jr would be the proper auto-injector.
EpiPens will need to be replaced no later than their expiration date, when the medication becomes less effective. You can find the expiration date on the medication box or on the device itself.

Frequently asked questions

See all Amazon One Medical FAQs

About EpiPens and anaphylaxis

What does an EpiPen do?
Epinephrine, the medication in an EpiPen, is the only effective treatment for anaphylaxis. After epinephrine is injected into the thigh of someone experiencing anaphylactic shock, the medication immediately starts working to reduce their symptoms.
While antihistamines can treat mild allergic reactions, there's no life-saving substitute for epinephrine when multiple organ systems are involved.
How much do EpiPens cost?
The cost of an EpiPen can vary widely depending on insurance coverage, pharmacy discounts, and whether you choose generic or brand-name medication. The U.S. Food and Drug Administration (FDA) approved generic EpiPen options in 2018, which lowered prices for many people at risk of anaphylaxis.
What can trigger anaphylaxis?
The most common triggers of anaphylaxis are medications (like antibiotics or NSAIDs), stinging insects (like bees, wasps, or fire ants), and foods (like shellfish, peanuts, or tree nuts). But in up to 20% of cases, the trigger is unknown.
Anaphylaxis can happen quickly after exposure to the allergen, normally within one to two hours, and sometimes within minutes. It can also reoccur up to 3 days after exposure in what's known as a biphasic reaction, which is why people at high risk should be monitored closely after an initial allergic reaction.
Did you know?
• Up to 51% of anaphylactic reactions happen at home
• 60% of U.S. adults who experience anaphylaxis don’t have epinephrine available
How do you recognize the signs of anaphylactic shock?
Someone with anaphylaxis might have a mild allergic reaction that rapidly gets worse, typically affecting their breathing. Most deaths from anaphylactic shock occur within the first hour. Multi-organ symptoms can include one or a combination of the following:
• Difficulty breathing
• Hives (skin rash with itchy bumps)
• Skin itching or flushing
• Swelling of the tongue, lips, or uvula
• Swelling or tightness in the throat
• Feeling like you have a "lump" in your throat
• Sudden persistent cough or throat clearing
• Wheezing
• Abdominal cramps or vomiting
• Incontinence
• Low blood pressure (systolic BP lower than 90 or at least 30% lower than usual)*
If you’re experiencing symptoms of anaphylactic shock, please call 911 or go to an emergency room (ER) as soon as possible.
*Low blood pressure (hypotension) can sometimes be the sole symptom of anaphylactic shock.

About EpiPens for children

What's the difference between EpiPen and EpiPen Jr.?
Both an EpiPen and EpiPen Jr. deliver the same active ingredient (epinephrine) in the same way, but they contain different doses in each injection. EpiPens deliver 0.3mg of epinephrine per injection while an EpiPen Jr., meant for smaller bodies, delivers 0.15mg.
A healthcare provider will prescribe an EpiPen or an EpiPen Jr. to your child based on their body weight.
What is the weight cut off for EpiPen Jr?
The weight cut off for EpiPen Jr. is typically 66 pounds.
When should a child learn to self-inject for anaphylaxis?
There is no guideline on when a child should learn to self-inject. The timing depends on the child’s ability after being trained on its use by the parent(s). Children have difficulties recognizing the symptoms of anaphylaxis (swelling of the lips/tongue/mouth, difficulty breathing, wheezing, difficulty swallowing, or rash), which is why parents of children who are at risk of experiencing ana[phylaxis should know how to properly administer an EpiPen.
If your child’s healthcare provider believes that your school-age child is too young to self-administer, it’s important to ensure that other adults at the school are aware of the possible risk of anaphylaxis in your child and how to properly administer an EpiPen.
Do I have to be the parent or guardian of the child seeking care?
Yes. A parent or legal guardian must initiate the child's care and be present during their treatment.
What type of healthcare provider will treat my child?
Children are treated by family practice physicians or licensed family nurse practitioners (FNPs). You'll be able to see the credentials of your child's provider after they're assigned to your child's treatment.
Can I get a doctor's note for my child?
Yes. After your child completes their treatment, their One Medical provider can write excused absence notes, back-to-school notes, and no-play notes for sports or other activities if medically appropriate.
What kind of online treatments can I request for my child?
At this time, parents and legal guardians can request treatments for their children aged 2 through 11 years old for the following health conditions through Amazon One Medical On-Demand Care (formerly Pay-per-visit):
• Head lice
• Pink eye
• Skin issue
• Eczema
• EpiPen prescription renewals
• Asthma prescription renewals
Clinical sources
1. Brown, J. C., Simons, E., & Rudders, S. A. (2020). Epinephrine in the Management of Anaphylaxis. The journal of allergy and clinical immunology. In practice, 8(4), 1186–1195.
2. Pflipsen, M. C., & Vega Colon, K. M. (2020). Anaphylaxis: Recognition and Management. American family physician, 102(6), 355–362.
3. Wood, R. A., Camargo, C. A., Jr, Lieberman, P., Sampson, H. A., Schwartz, L. B., Zitt, M., Collins, C., Tringale, M., Wilkinson, M., Boyle, J., & Simons, F. E. (2014). Anaphylaxis in America: the prevalence and characteristics of anaphylaxis in the United States. The Journal of allergy and clinical immunology, 133(2), 461–467.
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